Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1637 | Thyroid (non-cancer) | ICEECE2012

Evidence of humoral response to extracellular matrix proteins in Grave's diseace and thyroid associated ophtalmopathy

Romano M. , Capuani B. , Bei R. , Nucci C. , Pastore D. , Andreadi A. , Sconocchia G. , Caputo M. , Modesti A. , Lauro D. , Bellia A. , Bertoli A.

Thyroid Associated Ophtalmopathy (TAO) is considered one of the most difficult pathologies to treat and a big threat for Graves Disease (GD) patients. This has enhanced the interest in finding a marker that can predict the onset and the prognosis of TAO. It has been demonstrated that GD is a chronic inflamed tissue that there is a remodelling of the ECM structure which elaborate inflammatory signals itself and also promotes the recruitment of cells from the bloodstream; these ...